Analysis of Ethylene Oxide by Headspace Chromatography GC-9860 (PIP+FID)

Ethylene oxide is a commonly used sterilizing agent for medical devices, which has the characteristics of strong penetration ability and good sterilization effect, and is widely used in the disinfection of medical supplies. However, ethylene oxide itself is a toxic gas. If the sterilized product cannot fully evaporate the ethylene oxide gas and the residual toxicity reaches a certain level, it will pose a threat to the human body.
At present, the most effective method for detecting residual organic solvents in medical devices such as epoxyethane and packaging materials using headspace chromatography is headspace gas chromatography. The GC9860 dedicated gas chromatograph is combined with a headspace sampler to heat and equilibrate the tested sample (gas-liquid or gas-solid), directly extract the top gas and inject it into the gas chromatograph, and use a hydrogen flame to detect the composition and content of residual solvents. Headspace gas chromatography is easy to operate, has good separation efficiency, and high analysis efficiency. This instrument is particularly suitable for the analysis of volatile trace components and is an essential testing instrument for quality control of medical device sterilization.
Medical Device Ethylene Oxide Testing Instrument Configuration Table

Medical Device Ethylene Oxide Testing Instrument Configuration Table
Serial Number	name	Specification and model	unit	quantity	origin
1	gas chromatograph	GC-9860(PIP+FID)	tower	1	Beijing
2	Headspace sampler	AHS-610	tower	1	Beijing
3	Air generator	BF-2L	tower	1	Beijing
4	hydrogen generator	BF-300E	tower	1	Beijing
5	nitrogen cylinder		bottle	1	Beijing
6	Specialized chromatographic column	Stainless steel column Φ 3 * 2m	root	1	Beijing
7	Ethylene oxide standard sample	3ml (for content calibration)	branch	1	Tianjin
8	Chromatography workstation	BF-2002	cover	1	Zhejiang university
9	computer printer		tower	1	self-provide

The GC-9860 headspace gas chromatograph for ethylene oxide analysis is a cost-effective single detector model designed specifically for routine sample analysis, with all the advantages of a network chromatograph. Optional FID or TCD detector. It can be widely used for quality control and product testing in chemical, pharmaceutical, food and other fields.

Main technical indicators:
● Operation display: 192 * 64 dot matrix Chinese LCD
Temperature controlled area: 6 channels
Temperature control range: 8 ℃ to 400 ℃ above room temperature, increment: 1 ℃, accuracy: ± 0.1 ℃
● Program heating order: 8 orders
● Lift rate: 0.1-39 ℃/min (ordinary type); 0.1-80 ℃/min (high-speed type)
External events: 4 channels
● Sample injector types: packed column injector, capillary injector optional
Number of detectors: 1; FID、TCD， Optional
● Start injection: manual or automatic selection
● Communication interface: Ethernet: IEEE802.3

Technical specifications of detector
Hydrogen flame ionization detector (FID)
Detection limit: Mt ≤ 3 × 10-12g/s (n-hexadecane);
Noise: ≤ 5 × 10-14A
Drift: ≤ 1 × 10-13A/30min
● Linear range: ≥ 106
Maximum operating temperature: ≤ 450 ℃
Thermal conductivity detector (TCD)
Sensitivity: S ≥ 4000mV? Ml/mg (n-hexadecane) (magnification 1, 2, 4, 8 times optional)
Noise: ≤ 10 μ V
Baseline drift: ≤ 30 μ v/30min